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KMID : 0545120230330050634
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Journal of Microbiology and Biotechnology
2023 Volume.33 No. 5 p.634 ~ p.643
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Bulb of Lilium longiflorum Thunb Extract Fermented with Lactobacillus acidophilus Reduces Inflammation in a Chronic Obstructive Pulmonary Disease Model
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Eom Ji-Eun
Kim Gun-Dong
Kim Young-In
Lim Kyung-Min
Song Ju-Hye
Kim Yi-Seul
Cho Eun-Suk
Shin Su-Jin
Lim Eun-Yeong
Kim Ha-Jung
Kim Sung-Hoon
Lee Deuk-Sik
Lee So-Young
Shin Hee-Soon
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Abstract
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Chronic obstructive pulmonary disease (COPD), one of the leading causes of death worldwide, is caused by repeated exposure to harmful matter, such as cigarette smoke. Although Lilium longiflorum Thunb (LLT) has anti-inflammatory effects, there is no report on the fermented LLT bulb extract regulating lung inflammation in COPD. Thus, we investigated the protective effect of LLT bulb extract fermented with Lactobacillus acidophilus 803 in COPD mouse models induced by cigarette smoke extract (CSE) and porcine pancreas elastase (PPE). Oral administration of the fermented product (LS803) suppressed the production of inflammatory mediators and the infiltration of immune cells involving neutrophils and macrophages, resulting in protective effects against lung damage. In addition, LS803 inhibited CSE- and LPS-induced IL-6 and IL-8 production in airway epithelial H292 cells as well as suppressed PMA-induced formation of neutrophil extracellular traps in HL-60 cells. In particular, LS803 significantly repressed the elevated IL-6 and MIP-2 production after CSE and LPS stimulation by suppressing the activity of the nuclear factor kappa-light-chain-enhancer of activated B (NFκB) in mouse peritoneal macrophages. Therefore, our results suggest that the fermented product LS803 is effective in preventing and alleviating lung inflammation.
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KEYWORD
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Lilium longiflorum Thunb bulb, Lactobacillus acidophilus, chronic obstructive pulmonary disease (COPD), anti-inflammation
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